real treatment against Covid-19 or false hope?

real treatment against Covid-19 or false hope?
real treatment against Covid-19 or false hope?

What is colchicine?

It is an anti-inflammatory drug used in particular in the treatment and prevention of gout attacks, in pericarditis or familial Mediterranean fevers.

What does the study say?

“Colchicine reduced the risk of death or hospitalization in patients with Covid-19 by 21% compared to placebo,” according to the Montreal Heart Institute (ICM), which conducted a study on 4,488 patients . “In those patients with a proven diagnosis of Covid-19, colchicine resulted in reductions in hospitalizations by 25%, the need for mechanical ventilation by 50%, and deaths by 44%. This major scientific discovery makes colchicine the first oral drug in the world that could treat patients in the pre-hospital phase, ”writes the ICM in a press release. With one conclusion: “”Treating patients at risk of complications with colchicine as soon as the diagnosis of Covid-19 is confirmed by PCR makes it possible to reduce their risk of developing a severe form of the disease” and, consequently, to “reduce the number hospitalizations ”.

What are his limits ?

Nathan Peiffer-Smadja, infectious disease specialist at Bichat hospital, points out the limits of the study: “This is a randomized trial without medical contact.

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The information is transmitted by a press release which gives no figures, only percentages. And, if we read between the lines, it would seem that they have not reached significance on their primary endpoint, so they fall back on their secondary endpoint ”. In addition, “they indicate a reduction in the risk of death or hospitalization in a population where this risk is very low”, adds the doctor, who calls for the greatest caution on these results, pending further additional data. precise.

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A point of view shared by the French Society of Pharmacology and Therapeutics: “In the current state of knowledge, the effectiveness of colchicine in the prevention or treatment of Covid-19 infections has not been demonstrated. Its use cannot therefore be recommended in view of the current data for the treatment of Covid-19 ”.

What side effects?

“Colchicine is a molecule for which the therapeutic margin is very narrow. Between the effective dose and the toxic dose, there is almost nothing. It is a very dangerous molecule for this reason, insists Nathan Peiffer-Smadja.

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The infectious disease specialist also recalls that “colchicine poisoning cannot be cured”. So many reasons that call for caution.

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