Hydroxychloroquine shows no benefit, raises death risk: Study

Hydroxychloroquine shows no benefit, raises death risk: Study
Hydroxychloroquine shows no benefit, raises death risk: Study

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Jeddah - Yasmine El Tohamy - LONDON: A team of researchers has begun recruiting volunteers for clinical trials of a vaccine against COVID-19, while another team has started work on a treatment that may help critically ill patients recover from the disease.

Research at the Jenner Institute at Oxford University, carried out in conjunction with an organization called the Oxford Vaccine Group, has been ongoing since January, with scientists now looking to recruit in excess of 10,000 people to take part in further trials following preliminary efforts in April.
The trial, now in its second phase following preliminary testing on a small sample size of 160 patients, will involve people of all age demographics — from children older than 5 years to the elderly — to help test the effectiveness of the vaccine, called ChAdOx1 nCoV-19, in a wider variety of people.
The vaccine — which was developed using an altered virus that affects chimpanzees, combined with the virus that causes COVID-19 in humans, SARS-CoV-2 — had positive effects in animal trials.
It will now be given to subjects alongside a licensed vaccine, MenACWY, which is used to combat meningitis and blood poisoning, which will serve as a “control comparison.”
It is one of only four major vaccine trials currently taking place worldwide, though over 100 experimental vaccines are known to be in development.
The head of the Oxford Vaccine Group, Prof. Andrew Pollard, said: “The clinical studies are progressing very well, and we are now initiating studies to evaluate how well the vaccine induces immune responses in older adults, and to test whether it can provide protection in the wider population.”
Preparation for mass production of the vaccine is already underway in anticipation of the trial proving successful.
The Oxford team has said it expects to have around a million units of the vaccine ready for use by September should that prove to be the case.
This week, pharmaceutical giant AstraZeneca said it had the capacity to make a billion doses of the Oxford vaccine, and had secured an agreement to produce at least 400 million doses.
Meanwhile, scientists working at King’s College, London, as well as the city’s Francis Crick Institute and Guy’s and St. Thomas’ Hospital, have started clinical trials of a drug called interleukin 7 to test its effects on combating COVID-19.
Interleukin 7 is known to boost a certain kind of human immune system cell, known as a T-cell, which is vital for clearing the body of infection.
A common theme among particularly serious cases of COVID-19 is a low T-cell count, though it is not yet known why. It is hoped that the introduction of the drug to patients suffering low counts may aid their recovery. The Crick Institute’s Prof. Adrian Hayday said: “They (the T-cells) are trying to protect us, but the virus seems to be doing something that’s pulling the rug from under them, because their numbers (in tested patients) have declined dramatically.”
The team believes that as well as boosting T-cell levels in critical patients, the findings of the trial may help develop a “fingerprint test” to check T-cell levels in the blood, which could help identify at an early stage patients at risk of developing more critical symptoms.
The team also hopes it will lead to the development of a treatment specifically aimed at reversing the effects of T-cell decline in COVID-19 patients.
“The virus that has caused this completely earth-changing emergency is unique — it’s different. It is something unprecedented,” said Hayday. “This virus is really doing something distinct, and future research — which we will start immediately — needs to find out the mechanism by which this virus is having these effects.”

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