Real suffered a 0-1 home defeat Cadiz while Barcelona was beaten by the same goal line at Getafewho moved up to second in La Liga.
Real head coach Zinedine Zidane offered no excuses when the reigning champions lost to Cadiz for the first time.
Anthony Lozano’s goal in the first half was enough to create an unlikely victory for the newcomers, who at Estadio Alfredo Di Stefano blocked a second-half attack and Karim Benzema’s late attempt fell off the crossbar.
However, Barcelona failed to score a Jaime Mata penalty after 56 minutes at the Coliseum Alfonso Perez.
Lionel Messi struck a post in the first half but it was a frustrating evening for the Catalans as Getafe, who also met the woodwork in the closing stages, tied on points with leaders Madrid.
Barca’s first loss of the season under head coach Ronald Koeman leaves them ninth, three points behind but still with a game in hand.
Luis Suarez ‘early goal set Atletico Madrid on the way to a 2-0 win Celtic VigoSubstitute Yannick Carrasco added a second break.
Granada beat Sevilla 1-0 with a late goal from Yangel Herrera after the guests sent off midfielder Joan Jordan Moreno just before the break.
In Italy, Zlatan Ibrahimovic scored two goals in the first half – one from a rebound from his penalty – as Serie A leaders. AC Milan Beat city rivals Inter 2-1 to win the Derby della Madonnina.
Ibrahimovic, who was fit again after a positive Covid-19 test, put the Rossoneri in the lead after 13 minutes when he went home on the second try after Samir Handanovic saved his penalty.
It was soon 2-0 after a quick counterattack, Ibrahimovic hit Rafael Leao with a left cross.
Inter pulled back a goal from Romelu Lukaku after 29 minutes but it was AC Milan who took the booty to maintain their perfect start.
Champions Juventus – without isolating himself Cristiano Ronaldo – fought for a 1-1 draw Crotonewhere Federico Chiesa was shown a red card for the visitors on his debut.
Simy gave the hosts the lead from the penalty spot, but midfielder Chiesa, a cut-off date transfer from Fiorentina, set Alvaro Morata to level after 21 minutes.
Juve had dropped to 10 in the hour Chiesa showed a red card for a foul on Luca Cigarini – but thought they had won when Morata scored in the 76th minute, only to get VAR’s goal for a Rand Offside was excluded.
Naples are second after a 4-1 win AtalantaHirving Lozano scored a double in the first half. Sampdoria Sit in sixth place after they hit Lazio 3-0.
RB Leipzig With a 2-0 win over their Bavarian rivals, they were able to make a point at the top of the Bundesliga Augsburg.
Defender Angelino led the guests at halftime. Substitute Yussuf Poulsen scored in one second just after 66 minutes.
Bayern Munich won 4-1 in Arminia BielefeldThomas Muller and Robert Lewandowski both scored two goals and midfielder Corentin Tolisso was sent off late.
Due to the strict Covid-19 regulations, visitors had to use changing rooms in a nearby school before the game.
Borussia Dortmund are also on nine points from four games after a late goal from Marco Reus secured a 1-0 win at Hoffenheim.
Stuttgart won 2-0 at Hertha Berlin fourth, sit while fighting Mainz lost 1-0 at home to Bayer Leverkusen.
The late kick-off on Saturday looked Wolfsburg Draw 1-1 at Borussia Monchengladbach with a late goal from Wout Weghorst while it was also 1-1 in between Freiburg and Werder Bremen.
In France, Marseille dismiss Bordeaux 3-1 for a first Ligue 1 win in five games.
Florian Thauvin gave the hosts the lead after just five minutes, Jordan Amavi also scored in the second half.
A Pablo own goal provided late consolation from Bordeaux substitute Josh Maja.
Earlier, Lorient came from behind and won 3-1 in the fight Reims, who sent off midfielder Moreto Cassama and substitute Anastasios Donis in the closing stages.
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