Courtesy of Infobae
An antiviral drug, MK-4482 / EIDD-2801 or molnupiravir, is capable of completely eliminating the transmission of the coronavirus in 24 hours, according to research carried out by scientists from the Institute of Biomedical Sciences at Georgia State University, in United States.
“This is the first demonstration of an orally available drug that quickly blocks the transmission of SARS-CoV-2, so could change the rules of the game”Said the Doctor Richard Plemper, distinguished university professor in the state of Georgia and leader of the group that carried out the investigation, according to the site Science Daily.
If treatment is started on time, those infected could reap great benefits for themselves and the rest of society. On the one hand, stopping the progress of patients to a more serious illness that complicates their health, while at the same time it could shorten the period of infection and, in this way, alleviate the emotional and socioeconomic cost of the prolonged isolation of the patient. Thus, local outbreaks could be avoided.
“We observed from the beginning that MK-4482 / EIDD-2801 has a broad spectrum activity against respiratory RNA viruses and that oral treatment of animals infected with the drug reduces the number of viral particles spread by several orders of magnitude, dramatically reducing transmission”Plemper noted. These properties made of MK-4482 / EIDD / 2801 a powerful candidate for pharmacological control of COVID-19 disease”He added.
Molnupiravir is an antiviral drug developed at Emory University in Atlanta by its drug innovation company, Drug Innovation Ventures at Emory (DRIVE), which was licensed by Ridgeback Biotherapeutics, which partnered with Merck & Co. It was originally It is intended to treat the flu and prevents the virus from making copies of itself by creating errors during viral RNA replication.
In the study published in the scientific journal Nature Microbiology, Plemper’s team reused MK-4482 / EIDD-2801 against SARS-CoV-2 and used a ferret model to test the effect of the drug to stop the spread of coronavirus.
“We believe that Ferrets are a relevant transmission model because they easily spread SARS-CoV-2, but most do not develop a serious disease, which is very similar to the spread of SARS-CoV-2 in young adults, “said the Doctor Robert Cox, a postdoctoral fellow in the Plemper group and a co-lead author of the study, according to Science Daily.
“When we share the infected and then treat the source animals with untreated contact ferrets in the same cage, none of the contacts were infected”, He stated Josef Wolf, a doctoral student in Plemper’s lab and co-lead author of the study. Compared, all the contacts of the ferrets of origin that had received placebo became infected.
If this ferret-based data translates to humans, COVID-19 patients treated with the drug could become non-infectious within 24 hours of starting treatment.
MK-4482 / EIDD-2801 is located in advanced phase II / III clinical trials in those being tested in three different doses every 12 hours for five days in COVID-19 patients.
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