Patients diagnosed with Parkinson’s may actually have NIID, one study shows

Patients diagnosed with Parkinson’s may actually have NIID, one study shows
Patients diagnosed with Parkinson’s may actually have NIID, one study shows
Reviewed by Emily Henderson, B.Sc.9. November 2020

A joint study by the National Neuroscience Institute (NNI) and the Singapore General Hospital (SGH) found that patients diagnosed with Parkinson’s may actually have NIID.

NIID is a disabling neurodegenerative disease due to a gene mutation and has no effective treatment. Symptoms of NIID include dementia, parkinsonism, balance disorders, and numbness and weakness in the limbs.

A patient with NIID may or may not have symptoms depending on their age and stage of the disease. The severe form of NIID usually occurs in elderly patients who have developed the disease.

The team studied more than 2,000 study participants, including healthy individuals and those with Parkinson’s disease (PD), for more than a decade.

They were surprised to find NIID-causing mutations in those diagnosed with PD. Dr. Ma Dongrui, Senior Medical Laboratory Scientist, Department of Neurology, SGH and lead author of the study, said, “To the best of our knowledge, this is the first study to report PD patients with NOTCH2NLC gene mutations in NIID patients.

Fortunately, they responded better to PD medication than most PD patients. This suggests that there must be factors that can influence why some develop PD while many others develop the more severe form of NIID.

When analyzing the NIID gene, the team found a group of healthy participants with a “milder” form of mutation. Such a mutation in the NIID gene could indicate that there is a risk of developing NIID or PD.

Because NIID can go undetected, a high index of suspicion may also be required in PD patients.

With what we now know, it might be beneficial for clinicians to look out for cognitive impairment or imaging clues early on that might suggest NIID in patients diagnosed with PD. Also, because NIID is caused by a genetic mutation, it may be worth looking for family members of PD patients who may show signs of NIID. „

Tan Eng King, professor, assistant medical director, and research director, National Neuroscience Institute

Our results suggest that many neurodegenerative diseases may overlap and share a common etiology. Finding a common link and uncovering the reason why a similar gene mutation leads to both mild Parkinson’s disease and a severe form of NIID can help identify new drugs for these diseases, “continues Prof. Tan who is also the lead author of the study and is a senior advisor at the NNI Department of Neurology on the SGH campus.

Following this study, the team plans to conduct more studies to better understand the mechanism behind NIID and identify new drugs for this condition.

Further research is needed to understand whether the broad clinical phenotype of NIID is related to the subtle genetic differences in the NOTCH2NLC locus, race, or other factors. Long-term follow-up of carriers of the gene mutation with a PD phenotype can provide additional information.

The study results were published online in JAMA Neurology am 24. August 2020.

Those:

Journal reference:

Angry., et al. (2020) Association of NOTCH2NLC Repeat extensions with Parkinson’s disease. JAMA Neurology. doi.org/10.1001/jamaneurol.2020.3023.

These were the details of the news Patients diagnosed with Parkinson’s may actually have NIID, one study shows for this day. We hope that we have succeeded by giving you the full details and information. To follow all our news, you can subscribe to the alerts system or to one of our different systems to provide you with all that is new.

It is also worth noting that the original news has been published and is available at de24.news and the editorial team at AlKhaleej Today has confirmed it and it has been modified, and it may have been completely transferred or quoted from it and you can read and follow this news from its main source.

PREV Rising crime takes centre stage in New York mayoral race
NEXT India's lauds Gulf assistance in fighting COVID-19