Effects of Coronavirus Disease 2019 on Organ Transplantation

Transplant Proc. 2020, September 15: S0041-1345 (20) 32741-X. doi: 10.1016 / j.transproceed.2020.09.006. Online before printing.


BACKGROUND: As the novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), emerged as a virus pandemic, data is emerging on the clinical characteristics and outcomes of patients with SARS-CoV-2 infection who develop a Undergo organ transplant. The aim of this systematic review was to evaluate the currently published literature on the management, clinical course and outcome of SARS-CoV-2 infection in recipients of liver, kidney and heart transplants.

METHODS: We conducted a systematic review to assess the currently published literature regarding the management, clinical course, and outcome of SARS-CoV-2 infection in liver, kidney, and heart organ transplant recipients. Articles published up to June 2020 were searched in the MEDLINE, ClinicalTrials.gov and PubMed databases. We identified 49 eligible studies involving a total of 403 organ transplant recipients.

RESULTS: Older age, male sex, and pre-existing comorbidities, including hypertension and / or diabetes, were the most common predominant characteristics in organ transplant recipients. The clinical presentation ranged from mild to severe illness, including multiple organ failure and death. We found an overall mortality of 21%.

CONCLUSION: Our analysis suggests that all-cause mortality in organ transplant recipients receiving immunosuppressive therapy is not increased or is worse than mortality in the general SARS-CoV-2 surgical population. Our results suggest that transplant surgery and its immunosuppressive effects should not interfere with proper surgical care for patients in the SARS-CoV-2 era.

PMID: 33127076 | DOI: 10.1016 / j.transproceed.2020.09.006

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