Suspension in France of a trial with the drug Anakinra

Suspension in France of a trial with the drug Anakinra
Suspension in France of a trial with the drug Anakinra

A clinical trial in France evaluating the drug Anakinra in the management of Covid-19 has been suspended, due to unexplained excess mortality among patients treated according to preliminary results of the trial, indicates the drug agency ANSM.

This drug, Anakinra (trade name: Kineret), initially intended for rheumatic diseases, had given “encouraging” results for severe forms of Covid-19 disease by significantly reducing the risk of death and the need for ‘be put on a ventilator in intensive care, according to a study by a French medical team from the Paris Saint-Joseph hospital, published in the specialist journal The Lancet Rheumatology.

This safety information does not call into question the benefit / risk ratio of Anakinra when it is used in the validated indications of its marketing authorization (AMM) such as for example for rheumatoid arthritis, underlines the ANSM. .

The ANACONDA-COVID-19 trial involves around 30 patients. The interim review of the data showed early excess mortality in the group of patients treated with Anakinra compared to the group that did not receive this drug.

Anakinra targets, to block it, one of the cytokines, interleukin-1 (IL-1) involved in the “inflammatory storm” which results in acute respiratory distress syndrome (ARDS) requiring assistance with ventilation. artificial with the use of respirator.

A clinical trial in France evaluating the drug Anakinra in the management of Covid-19 has been suspended, due to unexplained excess mortality among patients treated according to preliminary results of the trial, indicates the drug agency ANSM.

This drug, Anakinra (trade name: Kineret), initially intended for rheumatic diseases, had given …


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