The Ruti vaccine against covid-19, developed by a researcher at Hospital Germans Trias i Pujol, in Barcelona, and manufactured by the Spanish pharmaceutical company Archivel Farma, is the first in Spain to receive authorization to carry out an international clinical test, which will be carried out in Argentina .
As informed by the company, the vaccine, initially designed against tuberculosis, should also be effective against other viral infections, such as the coronavirus, for which it received approval from the National Administration of Medicines, Food and Medical Technology (ANMAT) in Argentina to conduct a clinical test.
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This is a double-blind, placebo study lasting nine months to evaluate the effectiveness of the Ruti vaccine in preventing infection and reducing mortality by Covid-19 in healthcare professionals.
The vaccine was developed by Dr. Pere-Joan Cardona, of the Can Ruti Microbiology Service, and is based on the so-called “trained innate immunity”, that is, on stimulating the body’s immunity through the vaccine and “providing it with memory “to generate a better and faster response to virus exposure.
If its effectiveness is proven, Ruti can become the basis for broad-spectrum antiviral vaccines, thanks to its alternative mechanism for generating antibodies produced by classic vaccination.
In fact, this new therapeutic option could also be used as a first resource in the event of epidemics caused by new viruses or in mutations of pandemic viruses that cause existing vaccines to lose their initial effectiveness.
It can also be applied as a booster in populations that do not respond effectively to specific vaccines or as a complement to vaccines that generate antibodies, for example, those developed specifically for Covid-19.
“The concept of trained immunity appears as an interesting and innovative alternative to be explored as a prevention strategy, initially in health professionals”, explained the doctor responsible for the study in Argentina, Waldo Belloso, admitting that “obtaining specific vaccines of efficacy enough and available for widespread use will take time “.
After receiving the endorsement from the Argentine authorities, the company Ruti Immune, created by Archivel Farma to produce the vaccine, has already started the logistical procedures so that the doses reach the South American country and can begin to be administered to 369 employees from different countries. health centers.
In Spain, according to the company, the vaccine could also soon be tested in a very similar clinical trial by the Germans Trias i Pujol Institute.
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