Cyclosporine reduces mortality from Covid-19, study says

A team of Spanish researchers has found evidence in a retrospective study that the cyclosporine drug could reduce mortality from covid-19, although clinical trials are still needed to demonstrate these results.

Specifically, scientists, who have analyzed the treatments of more than 600 patients with covid-19, have found that those who received cyclosporine – a drug currently used in transplant patients– were 81% less likely to die than patients who did not receive this treatment.

The results of this observation are published in the journal E Clinical Medicine of the group The Lancet and the study is led by the Quirónsalud Madrid University Hospital, together with the European University.

To reach their conclusions, they analyzed the treatments of more than 600 patients with covid-19 admitted to the hospital from March 10 to April 15.

“In our series, patients who received cyclosporine were 81% less likely to die than patients who did not receive this treatment,” he explains in a note. Daniel Carnevali, Head of the Internal Medicine Service of the Quirónsalud Madrid University Hospital and professor at the aforementioned university.

This expert recalls that the disease by coronavirus SARS-CoV-2 does not yet have a standard treatment.

During the first stage of the pandemic, he explains, “we used therapies on which we had a reasonable hope that they would have an effect, but without clinical trials to support them: antimalarials such as hydroxychloroquine, antivirals such as Lopinavir-ritonavir, antibiotics, corticosteroids were used. and drugs that act in the inflammatory phase of the disease such as tozilizumab and cyclosporine “.

Also read: Covid-19: Remdesivir, dexamethasone and other drugs used against the pandemic

“The most surprising finding of our study is that patients who received cyclosporine had a longer survival compared to those who had not taken it,” emphasizes this researcher, who nonetheless emphasizes that “the results must be taken with caution.”

In this sense, he argues: our study is retrospective, it is not a double-blind randomized study comparing drug to drug.

“What we have verified is that patients who have received cyclosporine are not essentially different from other patients, suffered from similar comorbidities, and yet their clinical outcome has been better. “

And he concludes: “We have found evidence that cyclosporine could be a promising drug. To confirm this hypothesis, a clinical trial would be necessary in which it could be randomized between patients taking cyclosporine or placebo.”


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