Previous research indicates that oxytocin has a role in reducing inflammation, and it is produced in the brain and has a link with the reproduction and childbirth process.
One of the most dangerous complications of infection with the emerging corona virus, a condition called “cytokine storm”, is the result of a strong immune response in which body tissues are attacked and witnesses a sharp decline in T-cells, which are an essential part of the adaptive immune system.
Researcher Ali Emami, assistant graduate research assistant at the University of Toledo in Ohio, and colleagues used the US National Institutes of Health database to analyze the characteristics of genes treated with drugs closely related to oxytocin.
The researchers found that a single drug from this family called, carbetocin, has genes-identical properties that reduce the inflammatory markers that lead to a cytokine storm in critically ill Covid-19 patients.
The drug also, according to the study, activates T-cells, which decrease dramatically during the cytokine storm and play an important role in the immune response.
Carbitocin is similar to lopinavir, an antiviral drug that is being studied as a treatment for Covid-19.
All these factors indicate that oxytocin has the potential to be a targeted treatment for cytokine storms in patients with Covid-19, the researchers said in a press release issued by the American Physiological Society.
In their report, which was recently published online in the journal Physiological Genomics, the authors concluded that “understanding the mechanisms by which the oxytocin or the oxytocin system may be a new immune target is critical.”
However, they added, “the safety and efficacy of intravenous oxytocin in critically ill Covid-19 has yet to be evaluated.”
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