A large clinical study shows that colchicine, an anti-inflammatory drug, is effective in treating Covid-19 and reducing the risk of complications related to the disease, announced the Montreal Heart Institute (ICM).
The positive results of the COLCORONA study constitute a “major scientific discovery”, which makes colchicine – a potent anti-inflammatory drug used in the treatment of gout – “the first oral drug in the world that could treat pre-phase patients. -hospitable, “said the ICM in a statement released late Friday evening.
The results of the study “demonstrated that colchicine reduced the risk of death or hospitalization in patients with Covid-19 by 21% compared to placebo””, underlines the ICM.
25% reduction in hospitalizations
The study, conducted in Canada, the United States, Europe, South America and South Africa, involved 4,488 patients.
In 4,159 of these patients – whose diagnosis of Covid-19 was proven by a nasopharyngeal test (PCR) – colchicine “resulted in reductions in hospitalizations by 25%, in the need for mechanical ventilation by 50%, and 44% of deaths “, argues the institute.
Colchicine treatment is effective in preventing the phenomenon of “major inflammatory storm” and reducing the risk of complications related to Covid-19, explained Dr Jean-Claude Tardif, director of the ICM Research Center and principal investigator of the COLCORONA study.
“”We are pleased to offer the world’s first oral drug whose use could have a significant impact on public health and potentially prevent complications from Covid-19 in millions of patients,” he said.
>> To read also: When the sequelae of Covid-19 last: what the research says
“Effectiveness of colchicine”
“Big news: a Quebec study shows the effectiveness of colchicine to treat Covid-19“”, welcomed the Prime Minister of Quebec François Legault in a tweet.
The COLCORONA study was conducted “without contact”, with patients with Covid-19 who were not hospitalized at the time of inclusion, with at least one risk factor for complications.
“”This is the largest study in the world testing a drug administered orally in non-hospitalized patients with Covid-19,” says the ICM.
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