Discovery, published this Wednesday in the magazine “Nature”, had the collaboration of a Portuguese researcher.
Portuguese researcher Lúcia Moreira, doing her PhD at the University of Oxford, in the United Kingdom, is one of the authors of the article published, this Wednesday, in the scientific journal “Nature”, which demonstrates that the hormone that helps regulate bone mass it is also produced by the heart. The finding, which results from research funded in part by the British Heart Foundation (BHF), “paves the way for new treatments for arrhythmias,” the researcher told JN. It is estimated that 9% of Portuguese people over 65 years of age suffer from atrial fibrillation, the most common form of arrhythmia.
Until now, it was thought that the hormone calcitonin, which helps to regulate bone mass and also to reduce the scar tissue in the auricles of the heart, was produced only by the thyroid gland. The research, however, revealed that cells in the upper cavities of the heart produce approximately 16 times more calcitonin than thyroid cells. The information is relevant because this scar tissue makes it difficult for electrical impulses to pass and can trigger atrial fibrillation.
The team, which brought together researchers from the University of Montreal, Baylor College of Medicine in the USA and the University of Melbourne, also found that the calcitonin receptor is present in the auricular cells responsible for the production of collagen, one of the main components of the tissue healing. When the team treated these cells with calcitonin, they produced 46% less collagen.
The researchers hope that this new heart hormone and its receptor can help develop new cardiac treatments. Svetlana Reilly, the professor at the University of Oxford who led the study, told BHF that “calcitonin and its receptor may be the important piece missing from the atrial fibrillation puzzle. Now we need to explore how we can use this hormone to to treat people with atrial fibrillation and to understand when would be the best time to treat someone “.
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