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University of New Mexico researchers, who have researched a number of previously approved drugs, believe that they have identified a drug that would help speed up a patient’s recovery from SARS-CoV-2 infection, the virus that causes Corona.
Theodore Oprah, MD, professor of medicine and pharmaceutical sciences at the University of New Mexico, said remdesivir is a new antiviral drug that has been shown to shorten hospital stay for those recovering from the new coronavirus, but surprisingly there is a treatment that speeds up recovery The patient, according to the “Medicalxpress” website.
In a research paper published this week in ACS Pharmacology & Translational Science, Oprah and his colleagues, in partnership with a team at the University of Tennessee Health Sciences Center led by Professor Colin Johnson, reported that an ancient antimalarial drug called amodiaquine was effective in eliminating the Coronavirus in test tube experiments.
Theodore Oprah was one of three promising candidates used in a process that included studying the molecular properties of nearly 4,000 drugs approved for human use by the US Food and Drug Administration, and researchers hope to find drugs that target known vulnerabilities in the Covid-19 virus.
Theodore Oprah, author of the new research, said that the other two drugs, an antipsychotic called zuclofentexol, and a blood pressure medication called nebivolol, eliminated the Corona virus in the experiments, as researchers believe that any of these three drugs can be combined with remdesivir or an anti-viral drug called faviravir. To launch a stronger attack on COVID-19.
The researcher added that the combination of two drugs can mean that lower doses of each can be given, which reduces the possibility of negative reactions, and the use of two drugs reduces the possibility of the virus developing a mutation that makes it immune to treatment.
The researcher continues: “We have to think about it carefully. Instead of getting one drug, you have two, and they are more effective, we are trying to give the scientific community two properties instead of one.”
The researcher notes that many of the compounds that show antiviral activity in a laboratory environment do not have the same effect in living organisms, so the next step is to conduct clinical trials to see if the drugs work in patients with coronavirus.
The process of examining the drugs began with Oprah and his colleague Larry Sklar, a distinguished professor in the department of pathology, who used computational methods to identify candidate drugs to fight Corona by measuring their similarity to hydroxychloroquine, an anti-malarial drug that has been described as a treatment for Covid-19.
The candidate drugs were sent to Stephen Bradfoot, an assistant professor at the Center for Global Health, who tested the compounds against virus samples in his Level 3 biosafety laboratory, and later, University of Tennessee scientists repeated the experiments to provide independent confirmation of the results, and used an additional test that detects the drugs’ effectiveness against The virus, Oprah says.
Uses of the 3 candidate drugs to fight Corona
Amodiaquine, first made in 1948, is on the World Health Organization’s List of Essential Medicines, has a good safety profile and is widely used in Africa to treat malaria, while zuclofentexol has been used to treat schizophrenia since the 1970s, while Nebivolol has been used for high blood pressure since Late 1990s.
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