New Corona active ingredient discovered next to Biontech vaccine: Scientists with...

New Corona active ingredient discovered next to Biontech vaccine: Scientists with...
New Corona active ingredient discovered next to Biontech vaccine: Scientists with...
  • Researchers have a potential drug against Corona discovered.
  • The active ingredient could die Transferability from Covid-19 block as early as 24 hours after ingestion.
  • That would make the domestic quarantine shorten significantly.
  • Scientists speak of a “breakthrough”.

Possible corona drug could greatly reduce the incidence of infections: The number of cases of corona infections continues to rise. Although the vaccine from the company “Biontech” is to be approved in Europe at the end of this year, it is expected that Covid-19 will infect tens of thousands more in the new year. But researchers are now providing a small ray of hope: In America, a flu drug was discovered that is supposed to stop the virus transmission.

Drug should contain Corona: animal experiments are showing initial success

“MK-4482 / EIDD-2801” or “Molnupiravir” – this is how the drug is called by the scientist Richard Plemper and his colleagues in the specialist magazine Nature Microbiology speak. “Molnupiravir” was originally supposed to be developed as an influenza drug, the study says. But in the wake of the corona pandemic, the researchers at Georgia State University changed their goals and tried to develop an active ingredient against Covid-19.

The spread of the coronavirus in humans should be “simulated” using ferrets. The animals would resemble young adults in spreading the virus species. “We believe that ferrets are a relevant transmission model because they spread SARS-CoV-2 easily, but usually do not develop a serious disease,” explains Dr. Robert Cox, also part of the research team.

Some infected ferrets received the active ingredient “MK-4482 / EIDD-2801 “and were subsequently locked in the same cage together with non-infected animals. And the drug showed its effect: “Molnupiravir” was able to prevent even a single other healthy ferret from becoming infected with Sars-CoV-2. In the placebo group, however, all animals were infected, according to the study report.

Influenza drug against corona: drug could be a breakthrough

From their animal experiments, the scientists concluded that taking “molnupiravir” within 24 hours could completely block the transmission of the coronavirus. This makes it the first “orally available drug that quickly blocks the transmission of Sars-CoV-2,” said Plember.

In terms of its successful results, Georgia State University is already talking about a breakthrough. The drug is a “strong candidate” for containing the virus and has the ability to “change the game”.

The Corona Drug: Three Benefits of “Molnupiravir”

According to the research, “MK-4482 / EIDD-2801” would have three major advantages:

  • The active ingredient could prevent the progression to inhibit serious illnesses.
  • The The infection phase and the Quarantänezeit could shortened will.
  • The The chain of infection local outbreaks could be easier interrupted will.

This would make “Molnupiravir” a very powerful drug against Sars-CoV-2.

Are there any side effects? Human trials are still pending

If the drug works in the same way in humans, then Covid-19 patients would no longer be infectious just 24 hours after taking “MK-4482 / EIDD-2801”. “If the ferret-based data on the inhibition of SARS-CoV-2 transmission are also confirmed in humans, then patients with Covid-19 could become non-infectious just 24 to 48 hours after starting the oral intake of molnupiravir,” write Cox and his team.

Since “Molnupiravir” has only been tested on animals so far, no judgment can yet be made about possible side effects, duration of effect and length of treatment. Critics of the active ingredient claimed that treatment with the drug would lead to changes in the genetic make-up. The scientists rejected the criticism. The pharmaceutical company “Merk” is currently conducting a clinical study with around 1300 test persons. The results are expected next year.


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